Competition between the replication initiator DnaA and the sequestration factor SeqA for binding to the hemimethylated chromosomal origin of E. coli in vitro.
Identifieur interne : 000248 ( France/Analysis ); précédent : 000247; suivant : 000249Competition between the replication initiator DnaA and the sequestration factor SeqA for binding to the hemimethylated chromosomal origin of E. coli in vitro.
Auteurs : A. Taghbalout [France] ; A. Landoulsi ; R. Kern ; M. Yamazoe ; S. Hiraga ; B. Holland ; M. Kohiyama ; A. MalkiSource :
- Genes to cells : devoted to molecular & cellular mechanisms [ 1356-9597 ] ; 2000.
Descripteurs français
- KwdFr :
- Complexe ORC, Escherichia coli, Facteurs de transcription, Fixation compétitive (génétique), Méthylation de l'ADN (), Origine de réplication (génétique), Plasmides (génétique), Protéines Escherichia coli, Protéines bactériennes (génétique), Protéines bactériennes (métabolisme), Protéines bactériennes (pharmacologie), Protéines de fusion recombinantes (génétique), Protéines de fusion recombinantes (métabolisme), Protéines de la membrane externe bactérienne, Protéines de liaison à l'ADN (génétique), Protéines de liaison à l'ADN (métabolisme), Protéines virales (génétique), Régions promotrices (génétique) (génétique), Réplication de l'ADN (), Réplication de l'ADN (génétique), Site-specific DNA-methyltransferase (adenine-specific) (antagonistes et inhibiteurs), Sites de fixation (génétique), Séquence riche en AT (physiologie), Séquences d'acides nucléiques régulatrices (génétique).
- MESH :
- antagonistes et inhibiteurs : Site-specific DNA-methyltransferase (adenine-specific).
- génétique : Fixation compétitive, Origine de réplication, Plasmides, Protéines bactériennes, Protéines de fusion recombinantes, Protéines de liaison à l'ADN, Protéines virales, Régions promotrices (génétique), Réplication de l'ADN, Sites de fixation, Séquences d'acides nucléiques régulatrices.
- métabolisme : Protéines bactériennes, Protéines de fusion recombinantes, Protéines de liaison à l'ADN.
- pharmacologie : Protéines bactériennes.
- physiologie : Séquence riche en AT.
- Complexe ORC, Escherichia coli, Facteurs de transcription, Méthylation de l'ADN, Protéines Escherichia coli, Protéines de la membrane externe bactérienne, Réplication de l'ADN.
English descriptors
- KwdEn :
- AT Rich Sequence (physiology), Bacterial Outer Membrane Proteins, Bacterial Proteins (genetics), Bacterial Proteins (metabolism), Bacterial Proteins (pharmacology), Binding Sites (genetics), Binding, Competitive (genetics), DNA Methylation (drug effects), DNA Replication (drug effects), DNA Replication (genetics), DNA-Binding Proteins (genetics), DNA-Binding Proteins (metabolism), Escherichia coli, Escherichia coli Proteins, Origin Recognition Complex, Plasmids (genetics), Promoter Regions, Genetic (genetics), Recombinant Fusion Proteins (genetics), Recombinant Fusion Proteins (metabolism), Regulatory Sequences, Nucleic Acid (genetics), Replication Origin (genetics), Site-Specific DNA-Methyltransferase (Adenine-Specific) (antagonists & inhibitors), Transcription Factors, Viral Proteins (genetics).
- MESH :
- chemical , antagonists & inhibitors : Site-Specific DNA-Methyltransferase (Adenine-Specific).
- chemical , genetics : Bacterial Proteins, DNA-Binding Proteins, Recombinant Fusion Proteins, Viral Proteins.
- chemical , metabolism : Bacterial Proteins, DNA-Binding Proteins, Recombinant Fusion Proteins.
- chemical , pharmacology : Bacterial Proteins.
- chemical : Bacterial Outer Membrane Proteins, Escherichia coli Proteins, Origin Recognition Complex, Transcription Factors.
- drug effects : DNA Methylation, DNA Replication.
- genetics : Binding Sites, Binding, Competitive, DNA Replication, Plasmids, Promoter Regions, Genetic, Regulatory Sequences, Nucleic Acid, Replication Origin.
- physiology : AT Rich Sequence.
- Escherichia coli.
Abstract
Following replication initiation, the replication origin (oriC) in Escherichia coli enters a hemimethylated state at Dam methylation sites which are recognized by the SeqA protein. SeqA binds preferentially to hemimethylated GATC sequences of DNA in vitro. SeqA is essential for the synchronous initiation of chromosome replication from oriC copies in vivo.
DOI: 10.1046/j.1365-2443.2000.00380.x
PubMed: 11122375
Affiliations:
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pubmed:11122375Le document en format XML
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Taghbalout</name><affiliation wicri:level="1"><nlm:affiliation>Institut Jacques Monod, CNRS, Université Paris 6-7, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Jacques Monod, CNRS, Université Paris 6-7</wicri:regionArea><wicri:noRegion>Université Paris 6-7</wicri:noRegion><wicri:noRegion>Université Paris 6-7</wicri:noRegion></affiliation></author><author><name sortKey="Landoulsi, A" sort="Landoulsi, A" uniqKey="Landoulsi A" first="A" last="Landoulsi">A. Landoulsi</name></author><author><name sortKey="Kern, R" sort="Kern, R" uniqKey="Kern R" first="R" last="Kern">R. Kern</name></author><author><name sortKey="Yamazoe, M" sort="Yamazoe, M" uniqKey="Yamazoe M" first="M" last="Yamazoe">M. Yamazoe</name></author><author><name sortKey="Hiraga, S" sort="Hiraga, S" uniqKey="Hiraga S" first="S" last="Hiraga">S. Hiraga</name></author><author><name sortKey="Holland, B" sort="Holland, B" uniqKey="Holland B" first="B" last="Holland">B. Holland</name></author><author><name sortKey="Kohiyama, M" sort="Kohiyama, M" uniqKey="Kohiyama M" first="M" last="Kohiyama">M. Kohiyama</name></author><author><name sortKey="Malki, A" sort="Malki, A" uniqKey="Malki A" first="A" last="Malki">A. Malki</name></author></analytic><series><title level="j">Genes to cells : devoted to molecular & cellular mechanisms</title><idno type="ISSN">1356-9597</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AT Rich Sequence (physiology)</term><term>Bacterial Outer Membrane Proteins</term><term>Bacterial Proteins (genetics)</term><term>Bacterial Proteins (metabolism)</term><term>Bacterial Proteins (pharmacology)</term><term>Binding Sites (genetics)</term><term>Binding, Competitive (genetics)</term><term>DNA Methylation (drug effects)</term><term>DNA Replication (drug effects)</term><term>DNA Replication (genetics)</term><term>DNA-Binding Proteins (genetics)</term><term>DNA-Binding Proteins (metabolism)</term><term>Escherichia coli</term><term>Escherichia coli Proteins</term><term>Origin Recognition Complex</term><term>Plasmids (genetics)</term><term>Promoter Regions, Genetic (genetics)</term><term>Recombinant Fusion Proteins (genetics)</term><term>Recombinant Fusion Proteins (metabolism)</term><term>Regulatory Sequences, Nucleic Acid (genetics)</term><term>Replication Origin (genetics)</term><term>Site-Specific DNA-Methyltransferase (Adenine-Specific) (antagonists & inhibitors)</term><term>Transcription Factors</term><term>Viral Proteins (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Complexe ORC</term><term>Escherichia coli</term><term>Facteurs de transcription</term><term>Fixation compétitive (génétique)</term><term>Méthylation de l'ADN ()</term><term>Origine de réplication (génétique)</term><term>Plasmides (génétique)</term><term>Protéines Escherichia coli</term><term>Protéines bactériennes (génétique)</term><term>Protéines bactériennes (métabolisme)</term><term>Protéines bactériennes (pharmacologie)</term><term>Protéines de fusion recombinantes (génétique)</term><term>Protéines de fusion recombinantes (métabolisme)</term><term>Protéines de la membrane externe bactérienne</term><term>Protéines de liaison à l'ADN (génétique)</term><term>Protéines de liaison à l'ADN (métabolisme)</term><term>Protéines virales (génétique)</term><term>Régions promotrices (génétique) (génétique)</term><term>Réplication de l'ADN ()</term><term>Réplication de l'ADN (génétique)</term><term>Site-specific DNA-methyltransferase (adenine-specific) (antagonistes et inhibiteurs)</term><term>Sites de fixation (génétique)</term><term>Séquence riche en AT (physiologie)</term><term>Séquences d'acides nucléiques régulatrices (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Site-Specific DNA-Methyltransferase (Adenine-Specific)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Bacterial Proteins</term><term>DNA-Binding Proteins</term><term>Recombinant Fusion Proteins</term><term>Viral 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Replication</term><term>Plasmids</term><term>Promoter Regions, Genetic</term><term>Regulatory Sequences, Nucleic Acid</term><term>Replication Origin</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Fixation compétitive</term><term>Origine de réplication</term><term>Plasmides</term><term>Protéines bactériennes</term><term>Protéines de fusion recombinantes</term><term>Protéines de liaison à l'ADN</term><term>Protéines virales</term><term>Régions promotrices (génétique)</term><term>Réplication de l'ADN</term><term>Sites de fixation</term><term>Séquences d'acides nucléiques régulatrices</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines bactériennes</term><term>Protéines de fusion recombinantes</term><term>Protéines de liaison à l'ADN</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Protéines bactériennes</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Séquence riche en AT</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>AT Rich Sequence</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Escherichia coli</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Complexe ORC</term><term>Escherichia coli</term><term>Facteurs de transcription</term><term>Méthylation de l'ADN</term><term>Protéines Escherichia coli</term><term>Protéines de la membrane externe bactérienne</term><term>Réplication de l'ADN</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Following replication initiation, the replication origin (oriC) in Escherichia coli enters a hemimethylated state at Dam methylation sites which are recognized by the SeqA protein. SeqA binds preferentially to hemimethylated GATC sequences of DNA in vitro. SeqA is essential for the synchronous initiation of chromosome replication from oriC copies in vivo.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Hiraga, S" sort="Hiraga, S" uniqKey="Hiraga S" first="S" last="Hiraga">S. Hiraga</name><name sortKey="Holland, B" sort="Holland, B" uniqKey="Holland B" first="B" last="Holland">B. Holland</name><name sortKey="Kern, R" sort="Kern, R" uniqKey="Kern R" first="R" last="Kern">R. Kern</name><name sortKey="Kohiyama, M" sort="Kohiyama, M" uniqKey="Kohiyama M" first="M" last="Kohiyama">M. Kohiyama</name><name sortKey="Landoulsi, A" sort="Landoulsi, A" uniqKey="Landoulsi A" first="A" last="Landoulsi">A. Landoulsi</name><name sortKey="Malki, A" sort="Malki, A" uniqKey="Malki A" first="A" last="Malki">A. Malki</name><name sortKey="Yamazoe, M" sort="Yamazoe, M" uniqKey="Yamazoe M" first="M" last="Yamazoe">M. Yamazoe</name></noCountry><country name="France"><noRegion><name sortKey="Taghbalout, A" sort="Taghbalout, A" uniqKey="Taghbalout A" first="A" last="Taghbalout">A. Taghbalout</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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